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Big Data and Genomics is a Course

Big Data and Genomics

Self-paced
1.2 credits

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Full course description

The Georgia Clinical & Translational Science Alliance- Georgia CTSA and Southern California Clinical and Translational Science Institute - SC-CTSI have collaborated to provide free, high quality educational programs for clinical research professionals at novice to expert levels of experience. At the completion of each course or program, participants earn contact hours recognized by a certificate and/or badge.

Course Description:

The first human genetic blueprint has just turned 20; the era of exorbitant costs to analyze one genome has now evolved to the use of digital bar codes to sequence DNA. Because of the sizeable quantity of complex data associated with human genomes, genomics is now considered a “big data” field. Genomics data involves the curation of data that cuts across cancer datasets, COVID-19, pediatrics, Canine Data Commons to mention a few. Each genomics data point is potentially a patient’s hope and wish. How do we test the feasibility of these emerging technologies and make the data sets publicly available yet meet the highest standards of patient protection and respect? There are trade-offs between data utility and data privacy protection.

Course Topics:

  1. NIH Announces Two Integral Components of the Cancer Genome Atlas Pilot Project
    • Feasibility of using large-scale genome analysis technologies
    • How to make genomics data accessible while respecting the privacy of research participants?
    • Balance between data protection and data utility/value
  2. Translation Data Spheres, Fair and Transparent Data, Universal Consent
  3. Visualization of a Genome
  4. Single Nucleotide Polymorphism (SNPs), Copy Number Variants (CNVs), Read/Write Error Cancer has been progressively redefined over the past 20 years
    • Tumor, Cancer, and Metastasis: Length-scale and Time-scale Matter
    • Engineer’s Dream: Develop a Continuum
    • Potential Use of New Technologies
    • Cancer Genome Reveals Complex Landscape
    • Adding an Engineering Perspective
    • Potential Source of Variability
    • Maturity and Heterogeneity of Platforms
    • Rapid Acceleration from Stimulus Funding (2009-2011)
      • Metadata Matters
      • Personalized Oncology through Integrative High-throughput Sequencing
      • Drug Discovery and Development (CTD2 and NCI-MATCH Clinical Trial)
  5. Data shared in the Public Domain
    • NIH Genomics Data Community – continues to develop
    • Cancer Moonshot Summit – expansion of private companies donating their data
    • Precision Medicine Initiative – unable to share cancer data / difficulty in getting metrics on patients
    • Apollo Program – first integrated molecular driven cancer cares early discovery to clinical health care implementation system
    • Precision Health and Precision Oncology
    • Accelerating Therapeutics for Opportunities in Medicine (ATOM) Consortium
    • The Cancer Genome Atlas (TCGA) program – high-quality survival outcome analytics

Speaker:

Jerry S.H. Lee, PhD isthe Chief Science and Innovation Officer for the Lawrence J. Ellison Institute for Transformative Medicine and Associate Professor of Clinical Medicine and Chemical Engineering & Material Sciences at the USC. Prior to USC, Dr. Lee served as a Health Sciences Director within the National Cancer Institute’s Office of the Director. Through direct support and use of public-public/public-private partnerships, he deployed programs focused on the integration of advanced technologies, trans-disciplinary approaches, infrastructures, and standards, to accelerate the creation of publicly available, broadly accessible, multi-dimensional data, knowledge, and tools to empower the entire cancer research continuum for patient benefit. In 2016, Dr. Lee was assigned to Office of the Vice President to serve as the Director for Cancer Research and Technology for the White House Cancer Moonshot Task Force. A few key efforts he helped coordinate include the Applied Proteogenomics Organizational Learning and Outcomes (APOLLO) Network, international collaborations to share molecular characterization datasets, the Blood Profiling Atlas in Cancer pilot, as well as co-chairing an interagency group focused on cancer data and technology policy issues.Dr. Lee’s research involves elucidating the interplay between biophysical and biochemical drivers of age-related diseases. He is a member of the Department of Veterans Affairs’ National Research Advisory Council, the National Academies Board on Science, Technology, and Economic Policy’s Innovation Policy Forum, and the Health and Environmental Sciences Institute’s Board of Trustees. Dr. Lee earned his BS in biomedical engineering and PhD in chemical and biomolecular engineering from Johns Hopkins University. dr.jerry@usc.edu

Audience:

This symposium is designed for Clinical Research Coordinators, Project Managers, Monitors, Regulatory, Medical and Clinical Affairs Professionals, or junior faculty with three or more years of experience seeking to further develop clinical research skills and principles. Clinical research professionals should have responsibilities that include clinical trial start up planning, mentoring and complex issues involving site management, study management, and sponsor / CRO challenges.

Learner Level: Intermediate/Advanced

Learner Disclosures:

  • Accreditation Status: Emory Nursing Professional Development Center (ENPDC) is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s (ANCC) Commission on Accreditation.
  • Financial Relationships: ENPDC has evaluated everyone who has the ability to control content of this activity (planning committee members, subject matter experts, presenters) and found that no relevant financial relationships exist.
  • Awarding Contact Hours: To obtain contact hours participants must
    • Review the entire activity
    • Pass the quiz with 100% of questions answered correctly
    • Complete the evaluation at the end
    • Certificates will be distributed at the end of the evaluation.
  • Enduring Materials Dates:
    • Start Date: 06/17/2022
    • Expiration Date: 06/16/2025

Need Help with Registration? Please contact us at ene@emory.edu or 404-727-9208.

Program Information: This is the first course in a five (5) course program. To complete the entire program and earn a badge CLICK HERE.

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